To date, the computerized adaptive testing (CAT) version of the Neuro-quality of life (QOL) has not been assessed in a large sample of people with multiple sclerosis (MS).
The aim of this study was to assess the associations between the CAT version of Neuro-QOL and other clinical and patient-reported outcome measures.
Subjects (n = 364) enrolled in SysteMS completed the CAT version of the Neuro-QOL and the 36-Item Short Form Survey (SF-36) within 4 weeks of a clinical exam that included the Multiple Sclerosis Functional Composite-4 (MSFC-4). The correlations between the Neuro-QOL domains and the MSFC-4 subscores and the SF-36 scores were calculated. The changes over time in the Neuro-QOL and other measures were also examined.
The lower extremity functioning score of the Neuro-QOL showed the highest correlations with MSFC-4 components including Timed 25-Foot Walk, 9-Hole Peg Test, and cognitive score. The expected domains of the Neuro-QOL showed high correlations with the SF-36 subscores, and some Neuro-QOL domains were associated with many SF-36 subscores. There was limited longitudinal change on the Neuro-QOL domains over 12 months, and the change was not associated with change on other measures.
The CAT version of the Neuro-QOL shows many of the expected associations with clinical and patient-reported outcome measures.
Source: Multiple Sclerosis Journal.
Author: Healy, B.C., Zurawski, J., Gonzalez, C.T., Chitnis, T., Weiner, H.L., & Glanz, B.I. (2018).https://www.ncbi.nlm.nih.gov/pubmed/30381985